Keck School of Medicine Events
Keck School of Medicine Research Seminar Series
"Using Genomics to search for New Viral Causes and Treatments for Cancers"
Monday, February 25, 2013
11:30 AM - 1:00 PM
Norris Research Towers Aresty Auditorium
Patrick S. Moore, MD, MPH, Distinguished and American Cancer Society (ACS) Professor, Department of Microbiology and Molecular Genetics, University of Pittsburg, Director, Cancer Virology Program, University of Pittsburgh Cancer Institute. Dr. Shou-Jiang Gao will be presenting the introduction.
Although animal polyomaviruses, such as SV40, have been critical models in cancer research for over one-half century, polyomaviruses have not--until recently--been linked to human cancer. Using digital transcriptome subtraction, Merkel cell polyomavirus (MCV) was discovered in 2008 to infect most Merkel cell carcinomas, the most severe form of skin cancer. Normally, MCV is an common and asymptomatic infection of the human skin. In Merkel cell tumors, however, the virus integrates and undergoes mutations that eliminate viral replication but allow continued expression of viral oncogenes. MCV and MCC reveal a new model for carcinogenesis in which a rare combination of xenomutations to healthy skin flora initiate a deadly cancer. Using new sequencing technologies, the causes previously-unsuspected viral cancers can be uncovered and clues for new rational drug therapies can be designed. Patrick S. Moore, MD, MPH is a Distinguished and American Cancer Society (ACS) Professor in the Department of Microbiology and Molecular Genetics, University of Pittsburgh. He is Director of the Cancer Virology Program for the University of Pittsburgh Cancer Institute. Dr. Moore is recognized for his role, together with Dr. Yuan Chang—also an ACS Professor, in discovering and characterizing Kaposi sarcoma herpesvirus (KSHV or HHV8) and Merkel cell polyomavirus (MCV), the two most recently recognized human tumor viruses. Dr. Moore and Chang's laboratory maintain an active focus on basic and translational research for both KSHV and MCV. Dr. Moore has received the General Motors Cancer Research Foundation Mott Award, the Robert Koch Prize, the Meyenburg Cancer Research Prize as well as other awards, and 21 patents. He is a Thomson Reuter ISI Highly Cited Researcher with over 17,000 scientific citations since 1992. A native of Salt Lake City, he graduated from Westminster College in 1977. He received medical and graduate degrees from the University of Utah, Stanford University and University California, Berkeley and trained at the Centers for Disease Control as an Epidemic Intelligence Service (EIS) officer.
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