Keck School of Medicine Events
Center for Applied Molecular Medicine - USC Physical Sciences in Oncology Center Monthly Seminar Series
"Can Cancer Be Reversed by Engineering the Tumor Microenvironment?"
Friday, February 22, 2013
12:00 PM - 1:00 PM
HARKNESS AUDITORIUM HSC - Clinical Sciences Building, 2nd Floor 2250 Alcazar Street, Los Angeles, CA
Donald Ingber, MD, PHD, Professpr of Vascular Biology, Harvard Medical Scoolm Professor of Bioengineering, Harvard School of Engineering and Applied Sciences, Founding Director, Wyss Institute for Biologically Inspired Engineering, will be presenting. Pizza and Beverages will be served for attendees at 11:45 am.
This presentation will summarize studies carried out by my research group over the past thirty years that are based on the belief that cancer is a disease of development control, and that the production of cancer stem cells, epithelial- mesenchymal transactions, angiogenesis and unrestrained cell growth that drive tumor formation and metastatic progression result from abnormal alterations of the tissue microenvironment that feed back to influence gene expression. This view is supported by the finding that cancer cell growth, differentiation and apoptosis can be influenced by altering the non-genetic environmental factors, such as extracellular matrix and mechanical forces, and by theoretical and experimental studies which suggest that regulatory network to induce cell fate switching, The lecture will review this work, and present more recent experimental finding that support the possibility of developing cancer-normalizing therapeutics.
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