Keck School of Medicine Events
Keck School of Medicine of USC Research Seminar Series
"Discovery of the Extra Cellular Role for Heat Shock Protein-90 (Hsp90) in Wound Healing and Tumor Progression"
Monday, March 18, 2013
12:00 PM - 1:00 PM
Aresty Auditorium, Harlyne J. Norris Research Tower (NRT)
Wei Li, PhD, Professor, Director of GMCB (Genetics, Molecular and Cell Biology) Graduate Program, Director of Skin Cancer Program
Department of Dermatology, USC-Norris Comprehensive Cancer Center
Keck School of Medicine will be presenting
Abstract: Only studies of the past seven years have revealed a picture for when, how and why Hsp90 gets exported by both normal and tumor cells. Normal cells secrete Hsp90 in response to tissue injury. Tumor cells have managed to constitutively secrete Hsp90 for tissue invasion. A well-characterized function of secreted Hsp90? is to promote cell motility, a crucial event for both wound healing and cancer. The pro-motility activity of secreted Hsp90? resides within a 115-aa fragment, called F-5, between the linker region and middle domain. In normal tissue, topical application of F-5 promotes acute and diabetic wound healing far more effectively than US FDA-approved conventional growth factor therapy. In cancer, drugs that selectively target the F-5 region of secreted Hsp90 by cancer cells is predicted to be more effective and less toxic than those that target the ATPase of the intracellular Hsp90. USC owns both patents of these applications. Biography: After receiving his college education in Biology Major from Xinjiang University, People's Republic of China, Dr. Li came the US in 1985. He received a MS degree in 1988 and a PhD degree in 1991 from the Department of Developmental Biology and Cancer at the Albert Einstein College of Medicine, Bronx, New York City. Following a two-year post-doctoral/instructor fellowship with Dr. Joseph Schlessinger (Professor and Chairman) in the Department of Pharmacology at New York University Medical Center, he joined the faculty of the Ben May Institute for Cancer Research at the University of Chicago in the fall of 1993 as an Assistant Professor. He came to USC in the beginning of 1999. He is currently a Professor in the Department of Dermatology and the USC-Norris Cancer Center and the Director of the USC GMCB Graduate Program. His research programs have been supported from NIH since 1995.
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