Keck School of Medicine Events

Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC

"Cyclin-Dependent Kinases (Cdks) Regulate the Balance Between Symmetric and Asymmetric Divisions in Neural Stem Cells"
October 2013
Tuesday, October 1, 2013
12:00 PM - 1:00 PM
Broad CIRM Center Seminar Room

Philipp Kaldis, PhD, Institute of Molecular and Cell Biology (IMCB, Senior Principal Investigator IMCB, Adjunct Associate Professor National University of Singapore (NUS),Department of Biochemistry, will be presenting. Andrew McMahon, PhD, will be hosting this event.
During neurogenesis, cell cycle regulators play a pivotal role in ensuring proper proliferation, cell cycle exit, and differentiation of neural precursors. However, the precise role of cyclin-dependent kinases (Cdks) in these processes is not well understood. We have studied knockouts of Cdks in the mouse brain as well as in neural stem cells. Loss of Cdk activity results in premature differentiation of basal progenitor cells which decreases the number of neurons produced. I will discuss the effect of the length of the phases of the cell cycle on differentiation and potential substrates of Cdks that are crucial for differentiation. Our work hints that the cell cycle is intricately linked to the differentiation process.

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